140 Рђрѕрѕрѕсѓ -

Do you need focus on its impact or its oncology/cancer impact?

MicroRNA-140 is highly expressed in cartilage and is a master regulator of chondrocytes (the cells responsible for cartilage formation). 140 РђРЅРѕРЅСЃ

MicroRNA-140 (miR-140) is a small, non-coding RNA molecule that plays a critical role in human health and disease. It is primarily known for its essential functions in skeletal development and its dual role in cancer progression. 🦴 Role in Skeletal Development and Osteoarthritis Do you need focus on its impact or

In many malignancies—including breast, lung, prostate, and gastrointestinal cancers—miR-140 is significantly downregulated. It typically acts as a tumor suppressor by inhibiting cell proliferation, invasion, and metastasis while encouraging cell death (apoptosis). It is primarily known for its essential functions

A clinical review published on PubMed demonstrates that miR-140 heavily dictates how sensitive cancer cells are to chemotherapy drugs like doxorubicin, cisplatin, and temozolomide. Up-regulating its expression can actively enhance the efficacy of these treatments.

Research from Genes & Development highlights that miR-140 protects against osteoarthritis. It does this by regulating specific genes like ADAMTS5 , which is responsible for breaking down the cartilage matrix.