An SIS sex-structured influenza A model with positive case fatality in an open population with varying size

Muntaser Safan; Bayan Humadi; Muntaser Safan; Bayan Humadi

doi:10.3934/mbe.2024306

Mathematical Biosciences and Engineering

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If no family match exists, doctors search international registries (like Be The Match).

Before the new cells enter, the old system must be cleared. Patients undergo "conditioning"—intense chemotherapy or radiation.

This is the physically toughest phase, often involving fatigue and nausea. 2. "Day Zero": The Infusion

(caregivers, newly diagnosed patients, or medical students)

Despite the weight of the moment, the actual transplant isn't surgery.

A Guide To Bone Marrow Transplantation Access

If no family match exists, doctors search international registries (like Be The Match).

Before the new cells enter, the old system must be cleared. Patients undergo "conditioning"—intense chemotherapy or radiation.

This is the physically toughest phase, often involving fatigue and nausea. 2. "Day Zero": The Infusion

(caregivers, newly diagnosed patients, or medical students)

Despite the weight of the moment, the actual transplant isn't surgery.

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Figure 1. A schematic diagram for the transition between the various model states
Figure 2. A bifurcation diagram to explain the region of existence of forward/backward bifurcation based on values in the plane $ (g, r) $, given that all other model parameters are kept fixed. Simulations are done based on parameter values as shown in Table 2
Figure 3. A schematic bifurcation diagram in the plane $ (\beta, \lambda) $, in case of backward bifurcation, is shown here. The bifurcation point occurs at $ \beta = \beta_0 $, while the turning point occurs at $ \beta = \beta_1 $. The dashed curve corresponds to the endemic infection equilibrium corresponding to the smaller root of the Eq (3.19), while the solid curve corresponds to the endemic infection equilibrium corresponding to the higher root of the Eq (3.19). Both roots coalesce at the turning point
Figure 4. The effective threshold $ \beta^\star $ as a function of the relative transmissibility parameter $ r $. The solid curve is $ \beta^\star = \beta_0 $. Above the solid curve, the model has a unique endemic equilibrium. The broken curve is $ \beta^\star = \beta_1 $. Between the broken and solid curves, the model has two endemic equilibria, while below it the model has only shown the influenza-free equilibrium, but no endemic equilibrium. The left figure, Subfigure (a), is depicted with $ g = 0.1 < \ell_1 $, while the right Subfigure (b) is depicted with $ g = 1.5 > \ell_2 $. The values of the remaining parameters are as shown in Table 2
Figure 5. The plane $ (r, \mathcal{R}_0) $ is subdivided into regions according to the number of endemic equilibria in each region. The solid curve is $ \mathcal{R}_0 = 1 $ (i.e., $ \beta = \beta_0 $). Above the solid curve, the model has a unique endemic equilibrium (UEE). The broken curve is $ \mathcal{R}_0 = \mathcal{R}_0^1 = \beta_1/ \beta_0 $ (i.e., $ \beta = \beta_1 $). Between the broken and solid curves, the model has two endemic equilibria (TEE), while below it the model has no endemic equilibrium (NEE). The Subfigure (a) is depicted with $ g = 0.8 < \ell_1 $, while the Subfigure (b) is depicted with $ g = 1.5 > \ell_2 $. The values of the remaining parameters are as shown in Table 2
Figure 6. The endemic force of infection $ \lambda $ as a function of the basic reproduction number $ \mathcal{R}_0 $. The figures are produced with parameter values as shown in Table 2, except the parameters $ r $ and $ g $ are given values as presented in the head of each subfigure. The Subfigure (a) shows the appearance of backward bifurcation, while the Subfigure (b) shows only forward bifurcation. Here, $ \beta_0 = 1.7003, \lambda^\star = 0.0163, \beta_1 = 1.6958 $ and $ \mathcal{R}_0 = 0.9973 $
Figure 7. Time-dependent solution for: the proportion of susceptible males (part (a)), the proportion of infected males (part (b)), the proportion of susceptible females (part (c)), and the proportion of infected females (part (d)). The figure is produced with parameter values as shown in Table 2, except $ r = 2 $ and $ g = 0.8 $, while $ \beta $ is chosen so that $ \mathcal{R}_0 = 0.8 $, where no endemic equilibrium exists. In this case, the infection-free equilibrium attracts all the solutions
Figure 8. Time-dependent solution for: the proportion of susceptible males (part (a)), the proportion of infected males (part (b)), the proportion of susceptible females (part (c)), and the proportion of infected females (part (d)). The figure is produced with parameter values as shown in Table 2, except $ r = 2 $ and $ g = 0.8 $, while $ \beta $ is chosen so that $ \mathcal{R}_0 = 0.998 \in (\mathcal{R}_0^1, 1) $, where two endemic equilibria co-exist with the infection-free equilibrium (IFE). In this case, the IFE and the endemic equilibrium that corresponds to the solution $ \lambda^+ $ (defined in (3.35)) are locally stable and, therefore, they both attract the solutions
Figure 9. Time-dependent solution for: the proportion of susceptible males (part (a)), the proportion of infected males (part (b)), the proportion of susceptible females (part (c)), and the proportion of infected females (part (d)). The figure is produced with parameter values as shown in Table 2, except $ r = 2 $ and $ g = 0.8 $, while $ \beta $ is chosen so that $ \mathcal{R}_0 = 1.3 > 1 $, where a unique endemic equilibrium exists with the infection-free equilibrium (IFE). In this case, the IFE is unstable, while the endemic equilibrium corresponds to the solution $ \lambda^+ $ (defined in (3.35)) is locally stable and, therefore, attracts all solutions
Figure 10. The graphs in the Subfigures (a) and (b) show respectively the population size $ N $ and the endemic prevalence of infection $ p_I $ at equilibrium as functions of the basic reproduction number $ \mathcal{R}_0 $. Also, the Subfigures (c) and (d) show, respectively, the proportion of male and female subpopulations as functions of the basic reproduction number $ \mathcal{R}_0 $. However, the endemic prevalence of influenza infections within males and females as functions of the basic reproduction number $ \mathcal{R}_0 $ are drawn respectively in the Subfigures (e) and (f). The figure is produced with parameter values as shown in Table 2, except the parameters $ r $ and $ g $ are given the values $ r = 0.9 $ and $ g = 0.8, 1.1, 1.5 $ that generate forward bifurcation phenomenon
Figure 11. The graphs in the Subfigures (a) and (b) show respectively the population size $ N $ and the endemic prevalence of infection $ p_I $ at equilibrium as functions of the basic reproduction number $ \mathcal{R}_0 $. Also, the Subfigures (c) and (d) show, respectively, the proportion of male and female subpopulations as functions of the basic reproduction number $ \mathcal{R}_0 $. However, the endemic prevalence of influenza infections within males and females as functions of the basic reproduction number $ \mathcal{R}_0 $ are drawn respectively in the Subfigures (e) and (f). The figures are produced with parameter values as shown in Table 2, except the parameters $ r $ and $ g $ are given the values $ r = 1.2 $ and $ g = 0.8, 1.1, 1.5 $ that generate forward bifurcation phenomenon
Figure 12. The graphs in the Subfigures (a) and (b) show respectively the population size $ N $ and the endemic prevalence of infection $ p_I $ at equilibrium as functions of the basic reproduction number $ \mathcal{R}_0 $. Also, the Subfigures (c) and (d) show, respectively, the proportion of male and female subpopulations as functions of the basic reproduction number $ \mathcal{R}_0 $. However, the endemic prevalence of influenza infections within males and females as functions of the basic reproduction number $ \mathcal{R}_0 $ are drawn respectively in the Subfigures (e) and (f). The figures are produced with parameter values as shown in Table 2, except the parameters $ r $ and $ g $ are given the values $ r = 0.2 $ and $ g = 1.5 $ that generate backward bifurcation phenomenon
Figure 13. The graphs in the Subfigures (a) and (b) show respectively the population size $ N $ and the endemic prevalence of infection $ p_I $ at equilibrium as functions of the basic reproduction number $ \mathcal{R}_0 $. Also, the Subfigures (c) and (d) show, respectively, the proportion of male and female subpopulations as functions of the basic reproduction number $ \mathcal{R}_0 $. However, the endemic prevalence of influenza infections within males and females as functions of the basic reproduction number $ \mathcal{R}_0 $ are drawn respectively in the Subfigures (e) and (f). The figures are produced with parameter values as shown in Table 2, except the parameters $ r $ and $ g $ are given the values $ r = 2 $ and $ g = 0.8 $ that generate backward bifurcation phenomenon
Figure 14. The graphs in the Subfigures (a) and (b) show respectively the population size $ N $ and the endemic prevalence of infection $ p_I $ at equilibrium as functions of the basic reproduction number $ \mathcal{R}_0 $. Also, the Subfigures (c) and (d) show, respectively, the proportion of male and female subpopulations as functions of the basic reproduction number $ \mathcal{R}_0 $. However, the endemic prevalence of influenza infections within males and females as functions of the basic reproduction number $ \mathcal{R}_0 $ are drawn respectively in the Subfigures (e) and (f). The figures are produced with parameter values as shown in Table 2, except the parameters $ c_1, c_2, r $ and $ g $ are given the values $ c_1 = 0.005, c_2 = 0.007, r = 0.9 $ and $ g = 2 $ that generate forward bifurcation phenomenon

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A Guide To Bone Marrow Transplantation Access

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