Modern helpful papers are increasingly moving toward solutions. Recent work includes:
: Developing treatments like antisense oligonucleotides (ASOs) to reverse abnormal splicing caused by AIRE mutations.
: For example, researchers have identified unique variants in certain populations, like a deep intronic variant common in patients of Puerto Rican descent.
: Investigating how AIRE-dependent development of specific "early life" Tregs protects tissues from attack, which could lead to new immunotherapies for T1D and other autoimmune conditions.
Editorial: The Role of Aire, microRNAs and Cell ... - PMC - NIH
Modern helpful papers are increasingly moving toward solutions. Recent work includes:
: Developing treatments like antisense oligonucleotides (ASOs) to reverse abnormal splicing caused by AIRE mutations.
: For example, researchers have identified unique variants in certain populations, like a deep intronic variant common in patients of Puerto Rican descent.
: Investigating how AIRE-dependent development of specific "early life" Tregs protects tissues from attack, which could lead to new immunotherapies for T1D and other autoimmune conditions.
Editorial: The Role of Aire, microRNAs and Cell ... - PMC - NIH
