N(383)rar Access
The "helpful feature" associated with this specific location in the receptor is its role in —essentially acting as a molecular "on/off" switch for genes.
If you are looking for a physical tool rather than a biological term, Go to product viewer dialog for this item. N(383)rar
: Normally, the RAR works with another protein (RXR) to bind to DNA. The R383 area is part of the machinery that ensures genes are only turned on when the proper signal (ligand) is present. The "helpful feature" associated with this specific location
: The switch does not lock in forward or reverse, allowing you to spin it quickly like a thumb screw to tighten loose fasteners. The R383 area is part of the machinery
(often stylized with a trailing 'R' or 'rar' in search terms) is a popular .
: In certain medical conditions like Resistance to Thyroid Hormone (RTH) syndrome, a mutation at this specific spot (R383) impairs the receptor's ability to release "corepressors".
Looks like a cool build. Personally I hadn’t heard about Shaman King so I learned something knew. What I’m exited to see is Robin Hood using toxophilite or hooded champion ranger archetypes or some adventure time stuff.
If you look through the Iconic Design archives, I’ve done Princess Bubblegum and Ice King so far.
Added to my Iconic Design candidates list!
I’d really like to see build for the shieldmarshal PrC (Paths of Prestige). I assume a mix of ranger and gunslinger levels, but that might be a trap I’m not seeing.
Noted!
I can’t take, Weapon Focus: katana (1st), no BAB! or weapon proficiency! ???
You’re right that you can’t take it at 1st level (and the guide has been updated accordingly), but the weapon proficiency thing isn’t a problem. You can pick a feat whose prerequisites you meet only sometimes, for example, a barbarian with Strength 11 can take Power Attack even though she doesn’t qualify for it unless she’s raging. Similarly, you can pick Weapon Focus (katana) even though you only qualify for it when you’ve manifested your ancestral weapon as a katana.
If that ruling bothers you, you could also take the Heirloom Weapon trait and pick the katana. It’ll make you proficient with the katana as a two-handed weapon (since its martial), but not as a one-handed weapon (as that’s exotic). Alternatively, you could build Yoh as a dwarf or a kitsune, as those races have a 1/4 oracle favored class bonus that grants them proficiency with one weapon of their choice. Pick any weapon you want when you first take Weapon Focus at Level 3, then retrain the feat to the katana at Level 4 after you gain the bonus. (Of course, if you went dwarf or human, you’d lose one of the Extra Revelation abilities. I’d pick voice of the grave myself.)
I looked at doing this as a Kitsune, or Tengu, or Half-Elf. I think a Kitsune would work, I assume you would agree, I just need to stat it out.
I’m not familiar with that ruling? Nor would Heirloom Weapon work, for me, without that ruling.