Season 5 Episode 2: Not Cancerhouse M.d. :

In " Not Cancer " (Season 5, Episode 2), House M.D. delivers a classic race-against-time medical mystery where the "villain" is a ghost from the past. This episode is a significant pivot point for Gregory House, who is reeling from Wilson’s resignation and the death of Amber. 🏥 The Medical Mystery: The Donor's Ghost

: All victims received organs from the same donor four years prior. The Victims :

: For the first time, House admits that Wilson was his only friend, setting the stage for his mental decline later in the season. Not CancerHouse M.D. : Season 5 Episode 2

The episode contrasts Apple’s bleak view of reality with House’s own cynicism.

: An elderly man who received a kidney and is the only other survivor at the start. In " Not Cancer " (Season 5, Episode 2), House M

: House attempts to find a new best friend, even "auditioning" a doctor who likes monster trucks, but realizes no one can replace Wilson's unique dynamic.

With Wilson (Robert Sean Leonard) refusing to speak to him, House hires a private investigator, (Michael Weston), to "spy" on Wilson and his team. 🏥 The Medical Mystery: The Donor's Ghost :

: Apple begins to see the world as "ugly" and loses her vision, even though her eyes are physically healthy. 🩺 The Diagnosis: Cancer Stem Cells