Alex and Helm treat a 10-year-old boy named Gus who has a tumor and severe anemia. They discover he has "Golden Blood"—a type so rare only 50 people in the world have it.

Megan is stunned to find Teddy pregnant with Owen’s baby. She bluntly critiques Owen’s messy romantic history, pushing him to seek therapy.

Jo remains in a deep depression after meeting her birth mother. She shuts Alex out and spends her time drinking, leading Link to attempt an intervention by cleaning her apartment and bringing food.

Megan Hunt returns with a veteran, Caleb, who needs an abdominal wall and organ transplant. This marks Catherine Fox’s first surgery back after her own health battle.