The show is noted for its candid approach to medical issues that are often stigmatized or kept private:
Ashton Kutcher gives his first joint interview with his twin brother, Michael, discussing Ashton's battle with vasculitis and Michael's experience with cerebral palsy and a heart transplant. The Checkup with Dr. David Agus
Nick Cannon shares the devastating experience of losing his five-month-old son, Zen, to brain cancer. The show is noted for its candid approach
Amy Schumer opens up about her lifelong battle with the "lonely disease," including her decision to undergo a hysterectomy. The Checkup with Dr. David Agus