The game was directed by Takashi Oda and produced by Rikiya Nakagawa , with much of the original House of the Dead staff returning to refine the experience.

Players control AMS agents James Taylor or Gary Stewart , who are sent to investigate the disappearance of agent G. the-house-of-the-dead-2

Set on February 26, 2000, roughly 14 months after the "Curien Mansion Incident" of the first game, the story follows a massive undead outbreak in Venice, Italy. The game was directed by Takashi Oda and

The outbreak is orchestrated by Caleb Goldman , a billionaire scientist who believes humanity must be "reset" through the creation of his ultimate lifeform, the Emperor . the Emperor .