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Otoferlin engages the target membrane specifically through a large interface involving the N-terminal C2B and C-terminal C2F-C2G domains . Ca 2+raised to the 2 plus power
This molecular mechanism allows the ear to convert sound into neural signals at incredibly high speeds.
Structure and function of otoferlin, a synaptic protein of ... - PMC
Lack of functional otoferlin or its C2 domain interaction prevents proper vesicle docking, leading to profound deafness. Summary Table: Otoferlin C2 Interactions Function/Location C2B-C2G Main interface for membrane binding C2D Crucial Ca 2+raised to the 2 plus power binding site; mutations affect sound encoding C2F-C2G Rearrange upon membrane binding to close structure Target Membrane Membrane where vesicles are docked
The protein utilizes C2 domains to bridge synaptic vesicles to the plasma membrane (plasma membrane being the "target membrane").
It tethers vesicles to the plasma membrane, facilitating sound encoding.
Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission,
The study highlights that membrane binding involves a cooperative effort of multiple domains.
Otoferlin engages the target membrane specifically through a large interface involving the N-terminal C2B and C-terminal C2F-C2G domains . Ca 2+raised to the 2 plus power
This molecular mechanism allows the ear to convert sound into neural signals at incredibly high speeds.
Structure and function of otoferlin, a synaptic protein of ... - PMC tm,cc,jp
Lack of functional otoferlin or its C2 domain interaction prevents proper vesicle docking, leading to profound deafness. Summary Table: Otoferlin C2 Interactions Function/Location C2B-C2G Main interface for membrane binding C2D Crucial Ca 2+raised to the 2 plus power binding site; mutations affect sound encoding C2F-C2G Rearrange upon membrane binding to close structure Target Membrane Membrane where vesicles are docked
The protein utilizes C2 domains to bridge synaptic vesicles to the plasma membrane (plasma membrane being the "target membrane"). Otoferlin engages the target membrane specifically through a
It tethers vesicles to the plasma membrane, facilitating sound encoding.
Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission, - PMC Lack of functional otoferlin or its
The study highlights that membrane binding involves a cooperative effort of multiple domains.